Overview of topics in the lecture series "Molecular biology in Psychiatry"

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Introduction: Why bother with genes?

0.1. Historic background

0.2. Eugenics

0.3. Galton

0.4. Darvin

0.5 Objectives

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1 The fundamentals: The blueprint of an organism is in its genes

1.1. Mendel's Laws of inheritance

1.1. Single gene inheritance

1.2. Cell division

1.3. Crossing over

1.4. Pedigrees

1.5 Karyotype

1.5. Genetic maps

1.2. Molecular basis of inheritance: From Sequence to Function

2.1. DNA

2.2. Regulation of RNA expression

2.3. Similarities and Differences between Organisms

2.4. Structure of the cell nucleus, comparimantalisation

2.5 Trinucleotide expansion diseases

2.6 Databases and the Human genome project

2.7. What is a gene?

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1.3. Methods in molecular biology

3.1. Identification of genes

3.2. RFLP

3.3. PCR

3.4. Transgenic animals

3.5 Bioinformatics

1.4 How expression of genetic information is used to transduce signals

1.5. Measuring human behaviour: psycholgical testing and statistical description

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2. Looking for genes in an organism: Finding the blueprint

2.1. Multifactorial Inheritance

2.2. Human Genes and behaviour

2.1. Single Gene inheritance

2.2. Twin and adoptive studies

2.3. heritability

2.4. adoptive sudies

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2.3. Identification of Genes: from function to sequence

3.1. positional cloning

3.2. Assosiation studies

3.3 Animal models

3. Putting it all together: animal models and genetics of complex diseases

3.1 Animal models

3.2 repeat extention diseases

3.3. Alzheimer Disease

3.4. Schizophrenia

3.5. Affective disorders

3.6. Addiction, Psychopharmacology

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